Innovative Probiotic Lactic Yeast for the pharmaceutical, nutritional and agricultural industries

Gut Health

"Modern" lifestyle obliges us to find the right natural aid to counteract its negative consequences on our microbial balance, digestive health, immune health and mood. In multiple research and clinical studies, Turval B0399 reduces lifestyle induced gut discomfort when consumed daily. Clinical trials, described bellow, demonstrate that it can ameliorate IBS-like symptoms (occasional diarrhea, constipation and bloating) improving the quality of life and the overall wellbeing.
Besides, the particular enzymatic activity of this yeast helps digestion of complex carbohydrates such as lactose and pectans and may prevent the associated digestion problems.

  • Probiotic Lactic Yeast ® Kluyveromyces B0399: immune system stimulation, gut colonization, bifidobogenic effect and other strain specific, probiotic properties

    Trial 143: Potential probiotic Kluyveromyces marxianus fragilis B0399 modulates the immune response in Caco-2 cells and PBMCs and impacts on the human gut microbiota in an in vitro colonic model system.

    Pubblication:Appl Environ Microbiol. 2012 Feb;78(4):956-64. doi: 10.1128/AEM.06385-11. Epub 2011 Dec 9.

    Simone Maccaferri(a), Annett Klinder(b), Patrizia Brigidi(a), Piero Cavina(c), Adele Costabile(a)*

  • Gastric resistence and sattle in the intestine: Kluyveromyces B0399

    Trial#138:Administration of a yogurt enriched with Kluyveromyces marxianus fragilis B0399 and Bifidobacterium l. BB12: a study on its impact on the intestinal microbiota of subjects with dysfunctional symptomatology

    Gut Microbes. 2012 Sep-Oct;3(5):406-13. Epub 2012 Jun 20.

    Prof.Patrizia Brigidi*
    Dr. Simone Meccaferri*

  • Irritable Bowel Sindrome

    Trial#132 Clinical results of treatment with the lactic yeast Kluyveromyces B0399 for Irritable Bowel Sindrome. This study, based on the gathering of symtomatological data before and after the treatment, demonstrates that the prolonged use of Kluyveromyces marxianus fragilis B0399 significantly improves the clinical picture and above all improves the quality of life of these patients.

    Dr. Sandro Andreoli*
    Dr. Paola Lovrovich (statistical analysis)

  • Colonization of the gastrointestinal tract

    Trial#130.1: The ability of Kluyveromyces marxianus fragilis B0399 to pass through the gastric barrier and colonize the intestine - examination of human feces after oral uptake by healthy volunteers.

    Giorgio Mustacchi (Oncological Centre, Local Health N1-Trieste; Trieste University) ; Antonio Miclavez ; Alessandro Turello;
    Franca Bearzi;Flaviano Collavini; Paolo Valles.

  • Trial#125: Evaluation of the effects of a yogurt containing Kluyveromyces marxianus fragilis B0399 in patients suffering from Irritable Bowel Syndrome—a randomized, placebo controlled clinical study (abbreviated text)

    This study evaluates the effects of a yogurt formulated with a new lactic yeast,
    Kluyveromyces marxianus fragilis B0399, in patients suffering from IBS. A double blind, monocentric study, controlled against a yogurt containing S. thermophilus, Lb. bulgaricus and Bifidobacterium lactis BB12, in parallel groups, in patients affected by IBS. The subjects assigned to the treated group presented a global satisfaction significantly superior compared to the control group.

    Principal experimenter: Prof. Enrico Roda (Bologna University – Italy)
    Clinical experimenters: Prof. Gianluca Cornia, Dr. Andrea Lisotti
    Statistical analysis: Eng. Antonio Maria Morselli Labate
    Promoter: COOP Italia

  • Lactic yeast Kluyveromyces B0399 (Kluyver B0399) on patients suffering from irritable colon

    Trial#16:The use of Saccaromyces cerevisiae and Kluyveromyces fragilis B0399 is recommended in all cases of intestinal dismicrobism induced by organic diseases and/or antibiotics, but also for putting intestinal flora back in equilibrium in the syndrome of irritable colon.

    Dr. S. Andreoli – medical director of the Gastroenterologic Service of the Hospital S. Maria della Misericordia of Udine Italy;

  • EXPERTISE: Improved lactose utilisation as a footprint of domestication in the K. marxianus B0399 “fragilis” lineage

    Scientific expertise: "THE SCIENCE UNDERLYING TRADITIONAL HUMAN ACTIVITY FOR INDUSTRY EXPLOITATION OF KLUYVEROMYCES MARXIANUS – improved lactose utilisation as a footprint of domestication in the K. marxianus B0399 “fragilis” lineage

    by prof. John Morrissey
    Professor in Microbiology, University College Cork, Ireland
    Member of the International Commission for Yeasts (ICY)
    Editor in Chief, FEMS Yeast Research

Laboratori Turval Italia Srl – Head Office and Research Dpt: Friuli Innovazione - Scientific and Technological Park "L. Danieli"
via Jacopo Linussio, 51 – 33100 Udine (UD) – P. IVA 01883020305